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The most unique thing about monerans is that they are prokaryotes. Since they are prokaryotes, they don’t have nuclei or the different organelles of eukaryotes. Prokaryotes have a “naked” chromosome made up of one DNA molecule without some of the proteins found in eukaryotes. Some prokaryotes have small circular pieces of DNA called plasmids in addition to the major chromosome. The cell walls of most prokaryotes have a polysaccharide modified by polypeptides, or peptidoglycans.